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Xinxiang Lei, Ph. D Associate Professor NMR, Organic Chemistry, Natural products E-mail: xxlei@xingba8.org Phone: +86-577-86689197 Address: 3C302, South Campus, Wenzhou University |
Education
2007.09-2012.01 Ph.D., Medicinal Chemistry, Chengdu institute of biology, Chinese Academy of Sciences, China
2010.03-2011.02 Postgraduate Fellow, College of Medicine, Yale University, New Haven, USA.
2005.09-2007.06 M.S., Organic Chemistry, Wenzhou University, Wenzhou, China
1997.09-2001.06 B.S., Chemistry, South-Central University For Nationalities, Wuhan, China
Research Experience
2009.10-present Associate Professor, Wenzhou University, China
2005.10-2009.09 Assistant Professor, Wenzhou University, China
2001.08-2005.09 Research Assistant, Wenzhou Normal University, China
Research Interests
Nuclear Magnetic Resonance Spectroscopy, Residual Dipolar Couplings, Development Novel Alignment Media for Measurement of Anisotropic Parameters, Structure Elucidation of Natural Products, Chiral Recognition of Small molecules by NMR Spectroscopy.
Awards and Honors
Award for Science and Technology of China Association for Instrumental Analysis, 2014
Academic Positions
Set-up the Sino-German Symposium on Novel NMR method for Organic Chemistry, 2014
Selected Publications
[1]. Lei, XX; Xu, Z; Sun, H; Wang, S; Griesinger, C; Peng, L; Gao, C; Tan, RX; Graphene Oxide Liquid Crystals as a Versatile and Tunable Alignment Medium for the Measurement of Residual Dipolar Couplings in Organic Solvents. J. Am. Chem. Soc. 2014, 136, 11280?112832.
[2]. Han, WB; Lu, YH; Zhang, AH; Zhang, GF; Mei,YN; Jiang, N.; Lei, XX; Song, YC; Ng, SW; Tan, RX; Curvulamine, a New Antibacterial Alkaloid Incorporating Two Undescribed Units from a Curvularia Species. Org. Lett. 2014, 16, 5366–5369.
[3]. Ma, QZ; Ma, MS; Tian, HY; Ye, XX; Xiao, HP; Chen, LH*; Lei, XX* A Novel Amine Receptor Based on the Binol Scaff old Functions as a Highly Effective Chiral Shift Reagent for Carboxylic Acids. Organic Letters, 2012, 14 (23): 5813-5815.
[4]. He, DH; Zhou, Y; Ding, LS; Lei, XX; Xiao, HP; Qi, HY; Xu, HX.; Gymnotheloids A — C, three lignan alkaloids from Gymnotheca chinensis. J. Org. Chem. 2012, 77, 8435?8443.
[5]. Lei, XX; Xu, J; Ma, W; Qiao, C; Newman, MA; Hammond, SM; Huang, YQ. Determinants of mRNA recognition and translation regulation by Lin28. Nucl. Acids Res. 2012, 40, 5174-5184.
[6]. Liu, L; Ye, MD; Hu, Xg; Yu, XC*; Zhang, LX; Lei, XX*. Chiral Solvating Agents for Carboxyilc Acids Based on Salen Moiety. Tetrahedron: Asymmetry, 2011, 22, 1667-1771.
[7]. Jin, JY; Jing, W; Lei, XX; Feng, C. Peng, SP; Boris-Lawrie, K; Huang, YQ. Evidence that Lin28 stimulates translation by recruiting RNA helicase A to polysomes. Nucl. Acids Res. 2011, 39, 3724-3734.
[8]. Lei, XX*; Liu, L; Chen, XJ; Yu, XC; Ding, LS; Zhang, AJ*. Pattern-Based Recognition for Determination of Enantiomeric Excess, Using Chiral Auxiliary Induced Chemical Shift Perturbation NMR. Org. Lett. 2010, 12, 2540-2543.
[9]. Ye, XX; Lei, XX*; Chen, ZF; Zhang, LX; Zhang, AJ*. In Situ Measurement of the Enantiomeric Excess of Alcohols and Amines under Asymmetric Reduction Reaction by 1H NMR. Org. Lett. 2010, 12, 3238-3241.
[10]. Ai, Y; Yang, GZ*; Liu, JC; Chen, Y; Liu, L; Lei, XX*. Synthesis and structure elucidation of five new pyrimido[5,4-c]quinoline-4(3H)-one derivatives using 1D and 2D NMR spectroscopy. Magn. Reson. Chem. 2010, 48, 955-959.
Invited Lectures
[1]. Graphene Oxide-based Liquid Crystalline Phases as a New Alignment Medium for the Measurement of RDCs, Sino-German Symposium on Novel NMR-based Methods for Organic Structure Determination, Wenzhou, China, 2014
[2]. Chiral recognition of small molecule by NMR, 17TH National Conference on Organic Analysis and bioanalysis, Nanning, China, 2013