个人简介
吴华悦，男，汉族，浙江兰溪人，中共党员，二级教授，博士研究生导师。1984毕业于杭州大学化学系有机化学专业，同年进入温州师范学院任教，现任温州大学有机及药物化学研究所所长，有机化学硕士点负责人，浙江省新药创制平台理事会理事，浙江省新药创制科技服务平台温州工作站负责人。入选温州市“新世纪551人才工程”第一层次、温州大学“高级人才工程”，获温州大学“教坛名师”、研究生“我心目中的好导师”称号。指导的研究生硕士论文入选2008年度浙江省优秀硕士论文。主持和参加国家“十一五”科技支撑计划项目、国家自然科学基金等国家、省部级科研项目多项，以通讯作者身份在Org. Lett.; J. Org. Chem.; Adv. Synth. Catal.; Green Chem.; Chem. Commun.等国内外刊物上发表论文120余篇，授权发明专利60余项。获浙江省科学技术奖3项，目前正从事药物及中间体的合成研究和有机合成方法学研究，是省、市重大科技项目的评审专家。2009年被“Encyclopedia of Reagents for Organic Synthesis”创刊编辑Leo A. Paquette邀请撰写其中部分章节（Preparation and Application of Tris-1-naphthyl Phosphine），被 J. Am. Chem. Soc.; Org. Lett.; J. Org. Chem.; Langmuir 和 Green Chem. 等期刊选为审稿人。
代表论著
127. Limeng Zheng, Qinfang Jiang, Hanyang Bao, Bingwei Zhou, Shu-Ping Luo, Hongwei Jin, Huayue Wu,* and Yunkui Liu*. Tertiary Amines Acting as Alkyl Radical Equivalents Enabled by a P/N Heteroleptic Cu(I) Photosensitizer. Org. Lett., 2020, 22, 8888-8893.
126. Kai Chen, Wei Chen, Bing Han, Wanzhi Chen,* Miaochang Liu and Huayue Wu*. Sequential C−S and S−N Coupling Approach to Sulfonamides. Org. Lett., 2020, 22, 1841-1845.
125 Xinyu Zhang, Yibin Zhou, Mengzhu Wang, Yating Chen, Yunbing Zhou, Wenxia Gao, Miaochang Liu, Xiaobo Huang* and Huayue Wu*. Metal-Free Facile Synthesis of Multisubstituted 1-Aminoisoquinoline Derivatives with Dual-State Emissions, Chem Asian J. 2020, 15, 1692–1700.
124. Fuming Xiao, Mengzhu Wang, Yunxiang Lei,* Wenbo Dai, Yunbing Zhou, Miaochang Liu, Wenxia Gao, Xiaobo Huang* and Huayue Wu*. Achieving crystal-induced room temperature phosphorescence and reversible photochromic properties by strong intermolecular interactions. J. Mater. Chem. C 2020, 8, 17410–17416.
123. Fuming Xiao, Mengzhu Wang, Yunxiang Lei*, Yufeng Xie, Miaochang Liu, Yunbing Zhou, Wenxia Gao, Xiaobo Huang* and Huayue Wu*. An Unexpected 4,5-Diphenyl-2,7-naphthyridine Derivative with Aggregation-Induced Emission and Mechanofluorochromic Properties Obtained from a 3,5-Diphenyl-4H-pyran Derivative. Chem Asian J. 2020, 15, 3437–3443.
122. Yufeng Xie, Zhiqiang Wang, Xiaoqing Liu, Miaochang Liu, Yunxiang Lei,* Yunbing Zhou, Wenxia Gao, Xiaobo Huang* and Huayue Wu*. Synthesis and photophysical and mechanochromic properties of novel 2,3,4,6-tetraaryl-4H-pyran derivatives. CrystEngComm 2020, 20, 6529–6535.
121. Xinyu Zhang, Yibin Zhou, Mengzhu Wang, Yating Chen, Yunbing Zhou, Wenxia Gao, Miaochang Liu, Xiaobo Huang,* and Huayue Wu*. Metal-free facile synthesis of multisubstituted 1-aminoisoquinoline derivatives with dual-state emissions. Chem Asian J. 2020, 15, 1692–1700.
120. Pingshun Zhang, Wanzhi Chen*, Miaochang Liu and Huayue Wu*. Synthesis of 3 HCF2S Chromones through Tandem Oxa-Michael Addition and Oxidative Difluoromethylthiolation. Org. Lett., 2019, 21(23), 9326-9329.
119. Wei Chen, Kai Chen, Wanzhi Chen,* Miaochang Liu and Huayue Wu*. Well-Designed N Heterocyclic Carbene Ligands for PalladiumCatalyzed Denitrative C−N Coupling of Nitroarenes with Amines. ACS Catal., 2019, 9, 8110−8115.
118. Kai Chen, Wei Chen, Xiaofei Yi, Wanzhi Chen,* Miaochang Liu and Huayue Wu *.Sterically hindered N-heterocyclic carbene/palladium(II) catalyzed Suzuki–Miyaura coupling of nitrobenzenes. Chem. Commun., 2019, 55, 9287-9290.
117. Xiaofei Yi, Kai Chen, Wei Chen, Wanzhi Chen *, Miaochang Liu and Huayue Wu *. Synthesis of cyclic gem-dinitro compounds via radical nitration of 1,6-diynes with Fe(NO3)3·9H2O. Org. Biomol. Chem., 2019, 17, 4725-4728.
116. DongPing Luo, YangFeng Huang, XiaoYi Hong, Dingben Chen, GuoXing Li, XiaoBo Huang, WenXia Gao, MiaoChang Liu, YunBing Zhou,* and HuaYue Wu*. Phthalocyanine Zinc-catalyzed Hydroxylation of Aryl Boronic Acids under Visible Light. Adv. Synth. Catal., 2019, 361, 961–964.
115. Zhiqiang Wang, Mengzhu Wang, Jingqing Peng, Yufeng Xie, Miaochang Liu, Wenxia Gao, Yunbing Zhou, Xiaobo Huang,* and Huayue Wu*. Polymorphism and multicolor mechanofluorochromism of a D-π-A asymmetric 4H-pyran derivative with aggregation-induced emission property. J. Phys. Chem. C 2019, 123, 27742−27751.
114. Yating Chen, Xinyu Zhang, Mengzhu Wang, Jingqing Peng, Yunbing Zhou, Xiaobo Huang,* Wenxia Gao, Miaochang Liu, and Huayue Wu*. Mechanofluorochromism, polymorphism and thermochromism of novel D–π–A piperidin-1-yl-substitued isoquinoline derivatives. J. Mater. Chem. C 2019, 7, 12580–12587.
113. Yating Chen, Yibin Zhou, Zhiqiang Wang, Mengzhu Wang, Wenxia Gao, Yunbing Zhou, Miaochang Liu, Xiaobo Huang,* and Huayue Wu*. Enhanced mechanofluorochromic properties of 1,4-dihydropyridine-based fluorescent molecules caused by the introduction of halogen atoms. CrystEngComm 2019, 21, 4258–4266. (Front cover paper)
112. Yibin Zhou, Yating Chen, Chong Duan, Lintao Zeng, Miaochang Liu, Yunbing Zhou, Wenxia Gao, Xiaobo Huang,* and Huayue Wu*. AIE-active 1,4-Dihydropyridine-Based Dual-Phase Fluorescent Sensor with Multiple Functions. Chem. Asian J. 2019, 14, 2242 –2250. (Front cover paper)
111. Wei Liu, YaoQian Hu, XiaoYi Hong, GuoXing Li, XiaoBo Huang, WenXia Gao, MiaoChang Liu, Yuanzhi Xia, * YunBing Zhou* and HuaYue Wu*. Direct synthesis of 3-acylbenzothiophenes via the radical cyclization of 2-alkynylthioanisoles with a-oxocarboxylic acids. Chem. Commun., 2018, 54, 14148-14151.
110. Xiaobo Huang*, Lebin Qian, Yibin Zhou, Miaochang Liu, Yixiang Cheng*, Huayue Wu*. Effective Structural Modification of Traditional Fluorophores to Obtain Organic Mechanofluorochromic Molecules. J. Mater. Chem. C, 2018, 6, 5075–5096.
109. Feifei Wu, Wanzhi Chen,* Miaochang Liu, and Huayue Wu*. Catalyst-Controlled Regioselective Synthesis of α-Amino Oxime Esters from N-(Acyloxy)amides and 2H-Azirines. Eur. J. Org. Chem., 2018, 5553–5557.
108. Lidong Shan, Ge Wu,* Miaochang Liu, Wenxia Gao, Jinchang Ding, Xiaobo Huang and Huayue Wu*. α,β-Diaryl unsaturated ketones via palladiumcatalyzed ring-opening of cyclopropenones with organoboronic acids. Org. Chem. Front., 2018, 5, 1651–1654.
107. Dehua Hu, Miaochang Liu, Huayue Wu,* Wenxia Gao and Ge Wu *. Copper-catalyzed diarylation of Se with aryl iodides and heterocycles. Org. Chem. Front., 2018, 5, 1352–1355.
106. Wei Liu, Ge Wu*, Wenxia Gao, Jinchang Ding, Xiaobo Huang, Miaochang Liu*, Huayue Wu. Palladium-catalyzed Oxidative C=C Bond Cleavage with Molecular Oxygen: One-pot Synthesis of Quinazolinones from 2-Amino Benzamides and Alkenes. Org. Chem. Front., 2018, 5, 2734–2738.
105. Ge Wu*, Lin Min, Hongchen Li, Wenxia Gao, Jinchang Ding, Xiaobo Huang, Miaochang Liu, Huayue Wu*, Metal-Free Synthesis of Alkynyl Alkyl Selenides via ThreeComponent Coupling of Terminal Alkynes, Se, and Epoxides. Green Chem., 2018, 20, 1560-1563.
104. Pingshun Zhang, Shanfei Pan, Wanzhi Chen,* Miaochang Liu, Huayue Wu*, Palladium-Catalyzed Sequential Heteroarylation/Acylation Reactions of Iodobenzenes: Synthesis of Functionalized Benzo[d]oxazoles. J. Org. Chem. 2018, 83, 3354-3360.
103. Xin Zhang, Ge Wu*, Wenxia Gao, Jinchang Ding, Xiaobo Huang, Miaochang Liu*, Huayue Wu, Synergistic Photo-Copper-Catalyzed Hydroxylation of (Hetero)aryl Halides with Molecular Oxygen, Org. Lett. 2018, 20, 708-711.
102. Shuling Yu, Linjun Qi, Kun Hu, Julin Gong, Tianxing Cheng, Qingzong Wang, Jiuxi Chen*, and Huayue Wu*, The Development of a Palladium-Catalyzed Tandem Addition/ Cyclization for the Construction of Indole Skeletons. J. Org. Chem. 2017, 82, 3631-3638.
101. Chao Gao, Ge Wu*, Min Lin, Miaochang Liu, Wenxia Gao, Ginchang Ding, Jiuxi Chen, Xiaobo Huang, Huayue Wu*, Copper-Catalyzed Three-Component Coupling Reaction of Azoles, Se Powder, and Aryl Iodides. J. Org. Chem. 2017, 82, 250-255.
101. Yunxiang Lei, Dongliang Yang, Huaijie Hua, Chunhui Dai, Lianhui Wang, Miaochang Liu, Xiaobo Huang, Yang Guo, Yixiang Cheng, Huayue Wu*, Piezochromism, acidochromism, solvent-induced emission changes and cell imaging of D-pi-A 1,4-dihydropyridine derivatives with aggregation-induced emission properties. Dyes and Pigments 2016, 133, 261-272.
100. Dongping Luo, Ge Wu*, Hang Yang, Miaochang Liu, Wenxia Gao, Xiaobo Huang, Jiuxi Chen, Huayue Wu*, Copper-Catalyzed Three-Component Reaction for Regioselective Aryl- and Heteroarylselenation of Indoles using Selenium Powder. J. Org. Chem. 2016, 81, 4485-4493.
99. Lin Min, Ge Wu, Miaochang Liu, Wenxia Gao, Jinchang Ding, Jiuxi Chen, Xiaobo Huang, Huayue Wu*, Copper-Catalyzed Oxirane-Opening Reaction with Aryl Iodides and Se Powder. J. Org. Chem. 2016, 81, 7584-7590.
98. Yanze Liu, Yunxiang Lei, Miaochang Liu, Fei Li, Hongping Xiao, Jiuxi Chen, Xiaobo Huang, Wenxia Gao, Huayue Wu*, Yixiang Cheng, The effect of N-alkyl chain length on the photophysical properties of indene-1,3-dionemethylene-1,4-dihydropyridine derivatives. J. Mater. Chem. C 2016, 4, 5970-5980.
97. Yanze Liu, Yunxiang Lei, Fei Li, Jiuxi Chen, Miaochang Liu, Xiaobo Huang*, Wenxia Gao, Huayue Wu*. Jinchang Ding, Yixiang Cheng*. Indene-1,3-dionemethylene-4H-pyran derivatives containing alkoxy chains of various lengths: aggregation-induced emission enhancement, mechanofluorochromic properties and solvent-induced emission changes, J. Mater. Chem. C 2016, 4, 2862-2870.
96. Yalong Hu, Wenxia Gao*, Fang Wu, Huayue Wu, Bin He, Jing He*. Low molecular weight gels induced differentiations of mesenchymal stem cells, J. Mater. Chem. B, 2016, 4, 3504-3508.
95. Kaiwen Yang, Sicheng Wan, Binbin Chen, Wenxia Gao*, Jiuxi Chen, Miaochang Liu, Bin He, Huayue Wu*. Dual pH and temperature responsive hydrogels based on β-cyclodextrin derivatives for atorvastatin delivery, Carbohydrate Polymers, 2016, 136, 300–306.
94. Yunxiang Lei, Yanze Liu, Yang Guo, Jiuxi Chen, Xiaobo Huang*, Wenxia Gao, Lebin Qian, Huayue Wu*, Miaochang Liu, Yixiang Cheng*. Multi-Stimulus-Responsive Fluorescent Properties of Donor-π-Acceptor Indene-1,3-dionemethylene-1,4-dihydropyridine Derivatives, J. Phys. Chem. C 2015, 119, 23138-23148.
93. Shanfei Pan, Xueji Ma, Danni Zhong, Wanzhi Chen*, Miaochang Liu, and Huayue Wu*. Palladium-Catalyzed One-Pot Consecutive Amination and Sonogashira Coupling for Selective Synthesis of 2-Alkynylanilines, Adv. Synth. Catal. 2015, 357, 3052-3056.
92. Shixian Zhao, Ruicheng Yu, Wanzhi Chen*, Miaochang Liu, and Huayue Wu*. Efficient Approach to Mesoionic Triazolo[5,1?a]isoquinolium through Rhodium-Catalyzed Annulation of Triazoles and Internal Alkynes, Org. Lett. 2015, 17, 2828-2831.
91. Weiguang Yang, Rui Qiao, Jiuxi Chen*, Xiaobo Huang, Miaochang Liu, Wenxia Gao, Jinchang Ding, Huayue Wu*. Palladium-catalyzed cascade reaction of 2-amino-N-arylbenzohydrazides with triethyl orthobenzoates to construct indazolo[3,2-b]quinazolinones, J. Org. Chem. 2015, 80, 482-489.
90. Hui Li, Yang Guo, Guoxing Li, Hongping Xiao, Yunxiang Lei, Xiaobo Huang*, Jiuxi Chen, Huayue Wu*, Jinchang Ding, and Yixiang Cheng*. Aggregation-Induced Fluorescence Emission Properties of Dicyanomethylene-1,4-dihydropyridine Derivatives, J. Phys. Chem. C 2015, 119, 6737?6748.
89. Long Xu, Yalong Hu, Miaochang Liu, Jiuxi Chen, Xiaobo Huang, Wenxia Gao*, Huayue Wu*. Gelation properties and glucose-sensitive behavior of phenylboronic acid based low-molecular-weight organogels, Tetrahedron, 2015, 71, 2079-2088.
88. Yunxiang Lei, Hui Li, Xiaobo Huang*, Jiuxi Chen, Miaochang Liu, Wenxia Gao, Jinchang Ding, Dajie Lin, Huayue Wu*. Water-soluble benzoselenadiazole-based conjugated polymer fluorescent sensor with high selectivity for ferric ions and mercury ions and possible applications as integrated molecular logic gates, Tetrahedron, 2015, 71, 3453-3462.
87. Hui Li, Yang Guo, Yunxiang Lei, Gao, Wenxia Gao, Miaochang Liu, Jiuxi Chen, Yuefei Hu, Xiaobo Huang*, Huayue Wu*. Dyes Pigm. 2015, 112, 105-115.
86. Weiguang Yang, Jiuxi Chen*, Xiaobo Huang, Jinchang Ding, Miaochang Liu, Huayue Wu*. Pd-catalyzed intramolecular aerobic oxidative C-H amination of 2-aryl-3-(arylamino)quinazolinones: synthesis of fluorescent indazolo[3,2-b]quinazolinones, Org. Lett. 2014, 16, 5418-5421 (SCI-TOP, IF: 6.324). [Highlighted by Synfacts 2014, 1264.]
85. Yunxiang Lei, Hui Li, Wenxia Gao, Miaochang Liu, Jiuxi Chen, Jinchang Ding, Xiaobo Huang*, Huayue Wu*. J. Mater. Chem. C 2014, 2, 7402-7410.
84. Yan Shen, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Wenxia Gao, Xiaobo Huang, Huayue Wu*. Copper-catalyzed direct C-H arylation of pyridine N-oxides with arylboronic esters: one-pot synthesis of 2-arylpyridines, Chem. Commun. 2014, 50, 4292-4295.
83. Duanqin Li, Hui Li, Miaochang Liu, Jiuxi Chen, Jinchang Ding, Xiaobo Huang*, Huayue Wu*. A novel D-π-A conjugated polymer chemosensor based on benzo[c][1,2,5]selenadiazole for highly selective and sensitive recognition of mercury (II) ions, Macromol. Chem. Phys. 2014, 215, 82–89.
82. Zhongyan Chen, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Wenxia Gao, Xiaobo Huang, Huayue Wu*. Unexpected copper-catalyzed cascade synthesis of quinazoline derivatives, J. Org. Chem. 2013, 78, 11342-11348.
81. Xingyong Wang, Miaochang Liu, Long Xu, Qingzong Wang, Jiuxi Chen*, Jinchang Ding, Huayue Wu*. Palladium-catalyzed addition of potassium aryltri?uoroborates to aliphatic nitriles: synthesis of alkyl aryl ketones, diketone compounds, and 2 arylbenzo[b]furans, J. Org. Chem. 2013, 78, 5273-5281.
80. Weiguang Yang, Leping Ye, Dayun Huang, Miaochang Liu, Jinchang Ding,* Jiuxi Chen*, Huayue Wu. Copper-catalyzed intramolecular C-N bond formation reaction of 3-amino-2-(2-bromophenyl)dihydroquinazolinones: synthesis of indazolo[3,2-b]quinazolinones, Tetrahedron 2013, 69, 9852-9856.
79. Guowei Kang, Zhenli Luo, Chongxing Liu, Hang Gao, Quanquan Wu, Huayue Wu*, Jun Jiang*. Amino acid salts catalyzed asymmetric aldol reaction of tryptanthrin: a straightforward synthesis of phaitanthrin a and its derivatives, Org. Lett. 2013, 15, 4738–4741.【Highlighted by Synfacts 2013, 1298.】
78. Guowei Kang, Quanquan Wu, Miaochang Liu, Qingfang Xu, Zunyang Chen, Weilong Chen, Yuqiang Luo, Wei Ye, Jun Jiang*, Huayue Wu*. Catalytic stereoselective conjugate addition of oxindole to electron-deficient alkynes, Adv. Synth. Catal. 2013, 355, 315-320.【Highlighted by Synfacts 2013, 447.】
77. Xingyong Wang, Xiaodong Wang, Miaochang Liu,* Jinchang Ding, Jiuxi Chen,* Huayue Wu. Palladium-catalyzed reaction of arylboronic acids with aliphatic nitriles: synthesis of alkyl aryl ketones and 2-aryl benzofurans, Synthesis 2013, 45, 2241-2244.【Highlighted by Synfacts 2013, 1058.】
76. Fujun Duan, Miaochang Liu, Jiuxi Chen*, Jinchang Ding, Yuefei Hu, Huayue Wu*. Copper-catalyzed sequential arylation and intramolecular annulation of 2-(2-bromophenyl)-2,3-dihydroquinazolin-4(1H)-ones with amidines, RSC Adv. 2013, 3, 24001-24004.
75. Chaoyu Zhou, Wenxia Gao,* Kaiwen Yang, Long Xu, Jinchang Ding, Jiuxi Chen, Miaochang Liu, Xiaobo Huang, Shun Wang, Huayue Wu*. A novel glucose/pH responsive low-molecular-weight organogel of easy recycling, Langmuir 2013, 29, 13568?13575.
74. Duanqin Li, Hui Li, Miaochang Liu, Jiuxi Chen, Jinchang Ding, Xiaobo Huang*, Huayue Wu*. Synthesis, optical and electrochemical properties of novel D-π-A type conjugated polymers based on benzo[c][1,2,5]selenadiazole unit via alkyne module, Polymer 2013, 54, 6158-6164.
73. Duanqin Li, Miaochang Liu, Jiuxi Chen, Jian Lan, Xiaobo Huang*, Huayue Wu*. Synthesis and photoelectric properties of novel indeno[2,1-a]phenalene-based derivatives Dyes Pigm.2013, 97, 389-396.
72. Chaoyu Zhou, Wenxia Gao*, Guangmin Lu, Jinchang Ding, Xiuming Wu, Xiaobo Huang, Jiuxi Chen, Miaochang Liu, Jun Jiang, Huayue Wu*. Preparation, characterization and in vitro release of microparticles based on dextran-rosuvastatin conjugate, Carbohydr. Polym. 2013, 96, 156-162.
71. Miaochang Liu, , Shaomiao Lin, Jinchang Ding, Wenxia Gao, Huayue Wu, Jiuxi Chen*. Decarboxylation of isatoic anhydrides with disul?des: an ef?cient and general synthesis of S-aryl 2-aminobenzothioate derivatives, Tetrahedron 2013, 69, 2283-2288.
70. Xingyong Wang, Qingzong Wang, Jiuxi Chen, Miaochang Liu*, Jinchang Ding, Huayue Wu. Palladium-catalysed addition of potassium phenyltrifluoroborate to dinitriles: synthesis of diketone compounds, J. Chem. Res. 2013, 37, 470-472.
69. Fu-Jun Duan, Jinchang Ding, Hongjuan Deng, Dingben Chen, Jiuxi Chen, Miaochang Liu*, Huayue Wu*. An approach to the Paal–Knorr pyrroles synthesis in the presence of β-cyclodextrin in aqueous media, Chin. Chem. Lett. 2013, 24, 793–796.
68. Tieqiang Huang, Jinchang Ding, Miaochang Liu, Wenxia Gao, Huayue Wu, Jiuxi Chen*. Catalyst-free protocol for the synthesis of quinoxalines and pyrazines in PEG, J. Heterocyclic Chem. 2013, 50, 293-297.
67. Hongxin Liu, Huayue Wu*, Zhenli Luo, Jie Shen, Guowei Kang, Bidai Liu, Zhifu Wan, Jun Jiang*. Regioselectivity-reversed asymmetric aldol reaction of 1, 3-dicarbonyl compounds, Chem. Eur. J. 2012, 18, 11899-11903.
66. Dayun Huang, Jiuxi Chen,* Weixing Dan, Jinchang Ding, Miaochang Liu, Huayue Wu*. A metal-free sulfenylation and bromosulfenylation of indoles: controllable synthesis of 3-arylthioindoles and 2-bromo-3-arylthioindoles, Adv. Synth. Catal. 2012, 354, 2123-2128.
65. Jiuxi Chen,* Yong Peng, Miaochang Liu, Jinchang Ding, Weike Su, Huayue Wu*. Palladium-catalyzed aerobic oxidative coupling of acyl chlorides with arylboronic acids, Adv. Synth. Catal. 2012, 354, 2117-2122.
64. Jilei Zhang, Jiuxi Chen,* Miaochang Liu, Xingwang Zheng, Jinchang Ding, Huayue Wu*. Ligand-free copper-catalyzed coupling of nitroarenes with arylboronic acids, Green Chem. 2012, 14, 912-916.
63. Shaojin Gu, Bo Liu, Jiuxi Chen, Huayue Wu*, Wanzhi Chen*. Synthesis, structures, and properties of ruthenium(II) complexes of N-(1,10-phenanthrolin-2-yl)imidazolylidenes, Dalton Trans. 2012, 41, 962-970.
62. Jiuxi Chen*, Xingyong Wang, Xingwang Zheng, Jinchang Ding, Miaochang Liu, Huayue Wu*. Ligand-free copper-catalyzed O-arylation of nitroarenes with phenols, Tetrahedron 2012, 68, 8905-8907.
61. Gaigai Liang, Jing Chen, Jiali Chen, Wanmei Li, Jiuxi Chen,* Huayue Wu. Sc(OTf)3-catalyzed synthesis of thiosulfonates in ionic liquid-water, Tetrahedron Lett. 2012,53, 6768-6770.
60. Hui Xu, Wanzhi Chen,* Jiuxi Chen, Huayue Wu*. Stereoselective synthesis of (Z)-1,2-dithio-1-alkenes via copper-catalyzed thiolation of (Z)-2-bromovinyl sulfides, Synthesis 2012, 380–388.
59. Xiepeng Lin, Wenxia Gao,* Chenen Li, Jiuxi Chen, Chen Yang, Huayue Wu*. Nano-sized flake carboxymethyl cassava starch as excipient for solid dispersions, Int. J. Pharm. 2012, 423, 435-439.
58. Guangshu Lv, Fujun Duan, Jinchang Ding, Tianxing Cheng, Wenxia Gao, Jiuxi Chen*, Huayue Wu. Tandem base-free synthesis of β-hydroxy sulphides under ultrasound irradiation, J. Chem. Sci. 2012, 124, 1057–1062.
57. Quansheng Ding, Jilei Zhang, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Huayue Wu*. Tandem synthesis of 2,3-dihydroquinazolin-4(1H)-ones on grinding under solvent-free conditions, J. Heterocyclic Chem. 2012, 49, 375-380.
56. Gaigai Liang, Miaochang Liu, Jiuxi Chen,* Jinchang Ding, Wenxia Gao and Huayue Wu*. NBS-promoted sulfenylation of sulfinates with disulfides leading to unsymmetrical or symmetrical thiosulfonates, Chin. J. Chem.2012, 30, 1611-1616.
55. Ligand-free palladium-catalysed oxidative Heck reaction of 4-vinylpyridine with arylboronic acids: selective synthesis of (E)-4-styrylpyridines, Chuanli Shi, Jinchang Ding, Jun Jiang, Jiuxi Chen, Huayue Wu, Miaochang Liu*. J. Chem. Res. 2012, 322-325.
54. Hongjuan Deng, Yjing Fang, Gaowei Chen, Miaochang Liu, Huayue Wu, Jiuxi Chen*. Copper-catalyzed Clauson–Kass pyrroles synthesis in aqueous media, Appl. Organometal. Chem. 2012, 26, 164-167.
53. Guowei Kang, Jun Jiang*, Hongxin Liu and Huayue Wu*. Asymmetric organocatalytic synthesis of β-hydroxyynones with a quaternary carbon center under aqueous conditions, J. Braz. Chem. Soc., 2012, 23, 5-10.
52. Wei Lu, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Wenxia Gao, Huayue Wu*, Palladium-catalyzed decarboxylative coupling of isatoic anhydrides with arylboronic acids, Org. Lett. 2011, 13, 6114-6117.
51. Xingwang Zheng, Jinchang Ding, Jiuxi Chen*, Wenxiao Gao, Miaochang Liu, Huayue Wu*. The coupling of arylboronic acids with nitroarenes catalyzed by rhodium. Org. Lett., 2011, 13, 1726–1729.
50. Jilei Zhang, Jiuxi Chen,* Jinchang Ding a, Miaochang Liu, Huayue Wu. Copper-catalyzed arylation of indolin-2,3-ones with arylboronic acids, Tetrahedron 2011, 67, 9347-9351.
49. Hanmei Zheng, Jinchang Ding, Jiuxi Chen,* Miaochang Liu, Wenxia Gao, Huayue Wu*. Copper-catalyzed arylation of arylboronic acids with aldehydes, Synlett 2011, 1626-1630.
48. Jun Li, Danna Jiang, Jiuxi Chen,* Miaochang Liu, Jinchang Ding, Huayue Wu*. Eco-friendly synthesis of quinoxaline derivatives by grinding under solvent-free conditions. J. Heterocyclic Chem. 2011, 48, 403-406.
47. Wenxia Gao, Xiaoqing Lin, Xiepeng Lin, Jinchang Ding, Xiaobo Huang, Huayue Wu*. Preparation of nano-sized flake carboxymethyl cassava starch under ultrasonic irradiation. Carbohydr. Polym. 2011, 84, 1413–1418.
46. Yong Peng, Jiuxi Chen,* Jinchang Ding, Miaochang Liu, Wenxiao Gao, Huayue Wu*. Ligand-free copper-catalyzed arylation of olefins by the Mizoroki–Heck reaction. Synthesis 2011, 213-216.
45. Tieqiang Huang, Jun Li, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu*. Silica sulfuric acid (SSA)/peg as a recyclable system for the synthesis of quinoxalines and pyrazines, Synth. Commun. 2011, 41, 3334–3343.
44. Xiepeng Lin, Wenxia Gao*, Xiaobo Huang, Panlong Zang, Jiuxi Chen, Huayue Wu*. Morphology-controlled hollow nanospheres of functionalized dextran by self-assembly in aqueous solution. Carbohydr. Polym. 2010, 82, 460–465.
43. Qiang Zhang, Jiuxi Chen,* WenxiaGao, Jinchang Ding and Huayue Wu*. Copper-catalyzed one-pot synthesis of propargylamines via C–H activation in PEG. Appl. Organometal. Chem. 2010, 24, 809-812.
42. Weixing Dan, Hongjuan Deng, Jiuxi Chen*, Miaochang Liu, Jinchang Ding, Huayue Wu*. A new odorless one-pot synthesis of thioesters and selenoesters promoted by Rongalite?. Tetrahedron 2010, 66, 7384-7388.
41. Wenxue Guo, Guangshu Lv, Jiuxi Chen*, Wenxia Gao, Jinchang Ding, Huayue Wu*. Rongalite? and base-promoted cleavage of disulfides and subsequent Michael addition to α,β-unsaturated ketones/esters: an odorless synthesis of β-sulfido carbonyl compounds, Tetrahedron, 2010, 66, 2297–2300.
40. Xiaoling Xu, Jiuxi Chen*, Wenxia Gao, Huayue Wu*, Jinchang Ding, Weike Su. Palladium-catalyzed hydroarylation of alkynes with arylboronic acids, Tetrahedron, 2010, 66, 2433–2438.
39. Mingtiao Cai, Guangshu Lv, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu*. CAN/I2-catalyzed Chemoselective Synthesis of Thiosulfonates by Oxidation of Disulfides or Thiols Chem. Lett. 2010, 39, 368-369.
38. Shaomiao Lin, Jilei Zhang, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Weike Su, Huayue Wu*. An Approach to Synthesis of Thioesters and Selenoesters Promoted by Rongalite?, J. Braz. Chem. Soc., 2010, 21, 1616-1620.
37. Xiaoliang Yang, Chunmei Xu, Shaomiao Lin, Jiuxi Chen,*, Jinchang Ding, Huayue Wu*. Weike Su, Eco-Friendly Synthesis of 2-Substituted Benzothiazoles Catalyzed by Cetyltrimethyl Ammonium Bromide (CTAB) in Water, J. Braz. Chem. Soc., 2010, 21, 37-42.
36. Shuanghua Cheng, Jiu-Xi Chen,* Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu*. Oxidative esterification of aldehydes with alcohols and phenols in air, J. Chem. Res. 2010, 130-132.
35. Yali Xu, Jiuxi Chen, Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu*. Solvent-free synthesis of 3,5-di(hetero)aryl-1,2,4-thiadiazoles by grinding of thioamides under oxidative conditions. J. Chem. Res. 2010, 151-153.
34. Jiuxi Chen, Changfu Zhang, Wenxia Gao, Huile Jin, Jinchang Ding, Huayue Wu*. B2O3/Al2O3 as a new, highly efficient and reusable heterogeneous catalyst for the selective synthesis of β-enamino ketones and esters under solvent-free conditions, J. Braz. Chem. Soc., 2010, 21, 1552-1556.
33. Hanmei Zheng, Qiang Zhang, Jiuxi Chen, Miaochang Liu, Shuanghua Cheng, Jinchang Ding,* Huayue Wu*, Weike Su. Copper(II) acetate-catalyzed addition of arylboronic acids to aromatic aldehydes, J. Org. Chem. 2009, 74, 943-945.
32. Huilong Xiao, Jiuxi Chen, Miaochang Liu, Dongjian Zhu, Jinchang Ding*, Huayue Wu*. Trichloroisocyanuric acid (TCCA) as a mild and efficient catalyst for the synthesis of 2-arylbenzothiazoles, Chem. Lett. 2009, 38, 170-171.
31. Bing Zuo, Jiuxi Chen, Miaochang Liu, Huayue Wu*, Weike Su*. Yb(OTf)3-catalyzed synthesis of pyrroles under solvent-free conditions, Chin. Chem. Lett. 2009, 20, 423–426.
30. Bing Zuo, Jiuxi Chen, Miaochang Liu, Jinchang Ding; Huayue Wu*, Weike Su*. Scandium Triflate-catalysed synthesis of N-substituted pyrroles from amine and 2,5-dimethoxytetrahydrofuran, J. Chem. Res. 2009, 14-16.
29. Dongjian Zhu, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu*. Catalyst and Solvent-free Synthesis of Imidazo[1,2-a]pyridines, J. Braz. Chem. Soc. 2009, 20, 482-487.
28. Wei Xiong, Jiuxi Chen, Miaochang Liu, Jinchang Ding, Huayue Wu*, Weike Su*. A general and efficient synthesis of pyrazoles catalyzed by Sc(OTf)3 under Solvent-Free Conditions, J. Braz. Chem. Soc. 2009, 20, 367-374.
27. Tieqiang Huang, Qaing Zhang, Jiuxi Chen,* Wenxia Gao, Jinchang Ding, Huayue Wu*. Synthesis of quinoxalines catalysed by cetyltrimethyl ammonium bromide (CTAB) in aqueous media, J. Chem. Res. 2009, 761-765.
26. Dongjian Zhu, Jiuxi Chen, Dengze Wu, Miaochang Liu, Jinchang Ding, Huayue Wu*. An Efficient, Catalyst- and Solvent-free Synthesis of Imidazo-[1,2-a]pyridines and 2,4-Disubstituted Thiazoles on Grinding, J. Chem. Res. 2009, 84-86.
25. Wenxue Guo, Jiuxi Chen*, Dengze Wu, Jinchang Ding, Fan Chen, Huayue Wu*. Rongalite? promoted highly regioselective synthesis of β-hydroxy sulfides by ring opening of epoxides with disulfides, Tetrahedron 2009 ,65 , 5240–5243.
24. Dongjian Zhu, Jiuxi Chen, Huilong Xiao, Miaochang Liu, Jinchang Ding, Huayue Wu*, Efficient and expeditious synthesis of di- and trisubstituted thiazoles in PEG under catalyst-Free Conditions, Synth. Commun. 2009, 39, 2895–2906.
23. Jiuxi Chen, Xiaoliang Yang, Miaochang Liu, Huayue Wu*, Jinchang Ding, Weike Su, Approach to synthesis of β-enamino ketones and pyrroles catalyzed by gallium(III) triflate under solvent-free conditions, Synth. Commun. 2009, 39, 4180–4198.
22. Qiang Zhang, Chunmei Xu, Jiuxi Chen*, Xiaoling Xu, Jinchang Ding, Huayue Wu*. Palladium-catalyzed arylation of arylglyoxals with arylboronic acids, Appl. Organometal. Chem. 2009, 23, 524–526.
21. Wenxue Guo, Huile Jin, Jiuxi Chen*, Fan Chen, Jinchang Ding, Huayue Wu*. An Efficient Catalyst-Free Protocol for the Synthesis of Quinoxaline Derivatives under Ultrasound Irradiation, J. Braz. Chem. Soc. 2009, 20, 1674-1679.
20. Xiaoliang Yang, Yali Xu, Jiuxi Chen*, Jinchang Ding, Huayue Wu*, Weike Su. Sodium dithionite-promoted synthesis of 2-arylbenzothiazoles by reaction of 2,2-disulfanediyldianiline with aldehydes in water, J. Chem. Res. 2009, 682–685.
19. Huilong Xiao, Jiuxi Chen, Miaochang Liu, Huayue Wu*, Jinchang Ding. An Approach to Disulfide Synthesis Promoted bySulfonyl Chloride in Sodium Bicarbonate Aqueous Media, Phosphorus, Sulfur, and Silicon, 2009,184,2553–2559.
18. Mingtiao Cai, Jiuxi Chen, Xiaobo Huang, Miaochang Liu, Jinchang Ding*, Huayue Wu*. Synthesis of fluorinated β-carbolines by one-pot reaction, J. Chem. Res. 2008, 296-298.
17. Jinchang Ding,* Rong Xu, Miaochang Liu , Xi’an Chen, Huayue Wu*. Gallium triiodide as a highly efficient and mild catalyst for the diethyl acetalization of carbonyl compounds J. Indian Chem. Soc. 2008, 85, 566-568.
16. Changming Qin, Huayue Wu*, Jiuxi Chen, Miaochang Liu, Jiang Cheng,* Weike Su, Jinchang Ding. Palladium-catalyzed aromatic esterification of aldehydes with organoboronic acids and molecular oxygen, Org. Lett. 2008, 10, 1537-1540.
15. Qiang Zhang, Jiuxi Chen, Miaochang Liu, Huayue Wu*, Jiang Cheng,* Changming Qin, Weike Su, Jinchang Ding. Palladium-catalyzed addition of arylboronic acids to N-tosylarylimines, Synlett 2008, 6, 935-939.
14. Changming Qin, Jiuxi Chen, Huayue Wu*, Jiang Cheng, Qiang Zhang, Bing Zuo, Weike Su, Jinchang Ding. One-pot synthesis of diaryl ketones from aldehydes via palladium-catalyzed reaction with aryl boronic acids, Tetrahedron Lett. 2008, 49, 1884–1888.
13. Jiuxi Chen, Dengze Wu, Fei He, Miaochang Liu, Huayue Wu*, Jinchang Ding, Weike Su*. Gallium(III) triflate-catalyzed one-pot selective synthesis of 2,3-dihydro-quinazolin-4(1H)-ones and quinazolin-4(3H)-ones, Tetrahedron Lett. 2008, 49, 3814-3818.
12. Xian Chen, Huayue Wu*, Rong Xu, Miaochang Liu, Jinchang Ding, Weike Su. Gallium Trichloride–promoted highly regioselective ring opening of epoxides with NH4SCN and NaN3 in water, Synth. Commun. 2008, 38, 1855–1865.
11. Changfu Zhang, Jiuxi Chen, Xiaochun Yu, Xian Chen, Huayue Wu*, Jianping Yu. B2O3/Al2O3 as an efficient and recyclable catalyst for the synthesis of β-amino alcohols under solvent-free conditions, Synth. Commun. 2008, 38, 1875–1887.
10. Fei He, Huayue Wu, Jiuxi Chen, Weike Su. Unexpectedly high activity of Zn(OTf)2?6H2O in catalytic Friedel–Crafts acylation reaction, Synth. Commun. 2008, 38, 255–264.
9. Jiuxi Chen, Miaochang Liu, Xiaoliang Yang, Jinchang Ding, Huayue Wu*. Indium(III)-catalyzed synthesis of N-substituted pyrroles under solvent-free conditions, J. Braz. Chem. Soc. 2008, 19, 877-883.
8. Jiuxi Chen, Weike Su,* Huayue Wu*, Miaochang Liu, Can Jin. Eco-friendly atsky reaction, Synthesis, 2007, 3233-3239.
7. Xian Chen, Changfu Zhang, Huayue Wu*, Xiaochun Yu, Weike Su*, Jiang Cheng. Solvent-free synthesis of β-hydroxy esters and β-amino esters by indium-mediated Reform123. Kai Chen, Wei Chen, Bing Han, Wanzhi Chen,* Miaochang Liu and Huayue Wu*. Sequential C−S and S−N Coupling Approach to Sulfonamides. Org. Lett., 2020, 22, 1841-1845.
6. Changming Qin, Huayue Wu*, Jiang Cheng*, Xi’an Chen, Miaochang Liu, Weiwei Zhang, Weike Su, Jinchang Ding. The palladium-catalyzed addition of aryl- and heteroarylboronic acids to aldehydes, J. Org. Chem. 2007, 72, 4102-4107.
5. Jiuxi Chen, Huayue Wu*, Weike Su. A facile synthesis of 2,3-dihydro-2-aryl-4(1H)-quinazolinones catalyzed by scandium(III) triflate, Chin. Chem. Lett. 2007, 18, 536–538.
4. Xian Chen, Huayue Wu*, Weike Su, Rong Xu, Miaochang Liu, Jinchang Ding. Active Metallic Indium-mediated ring-opening of epoxides with diphenyl diselenides: a novel one-pot synthesis of β-hydroxy selenides in aqueous media, J. Chem. Res. 2007, 325-327.
3. Weike Su, Jiuxi Chen, Huayue Wu, Can Jin. A general and efficient method for the selective synthesis of α-hydroxy sulfides and β-hydroxy sulfoxides catalyzed by gallium(III) triflate, J. Org. Chem., 2007, 72, 4524-4527.
2. Jiuxi Chen, Huayue Wu, Can Jin, Xingxian Zhang, Yuanyuan Xie, Weike Su. Highly regioselective ring-opening of epoxides with thiophenols in ionic liquids without the use of any catalyst, Green Chem. 2006, 8, 330–332.
1. Jiuxi Chen, Huayue Wu, Zhiguo Zheng, Can Jin, Xingxian Zhang, Weike Su. An approach to the Paal–Knorr pyrroles synthesis catalyzed by Sc(OTf)3 under solvent-free conditions, Tetrahedron Lett. 2006, 47, 5383–5387.
主要项目
1. 《过渡金属/环丙鎓离子体系协同活化酚C-O键的偶联反应研究》国家自然科学基金(21472140) 2015年1月-2018年12月，项目负责人，
2.《过渡金属催化有机硼试剂参与的插硒反应研究》国家自然科学基金(21272176)，2013年1月-2016年12月，项目负责人
3.《基于氢键活化环氧化物的不对称开环反应研究》国家自然科学基金( 21072153)，2011年1月-2013年12月，项目负责人
4.《绿色化学合成技术及应用创新团队》浙江省科技创新团队(2009R50002)，2010年7月-2012年7月，子课题负责人
5.《头孢、碳青霉烯系列原料药的绿色合成技术集成与示范》，国家“十一五”科技支撑计划(2007BAQ00155)，2007年8月-2010年12月，国家科技部，第二负责人
6.《华基化工股份有限公司全面合作协议》，横向委托，2009年3月-2012年3月，负责人
7.《头孢系列活性酯的绿色合成技术开发》，浙江省绿色化工重大专项（2006C11022），2006年6月，浙江省科学技术厅，子课题负责人
8.《纺织助剂十八烷基乙烯脲的清洁生产技术开发》浙江省科技计划项目（2005C31036），2005年01月，浙江省科学技术厅，项目负责人
9.《聚对芳撑乙炔类高聚物的合成、修饰及表征》，浙江省自然科学基金（Y405015），2006年01月，项目负责人
10.《医药中间体2-氯苯并咪唑的合成研究》，浙江省科技计划项目（2003C31026），2003年01月，浙江省科学技术厅，项目负责人
11.《吡咯酯的合成研究》，横向委托项目，2004年12月，项目负责人
12.《辣椒素微胶囊的研制及其在电线、电缆护套线防鼠咬应用研究》，横向委托项目，2004年12月，项目负责人
13.《炔草酯原药研制开发》，招标项目，2004年11月，项目负责人
14.《邻乙氧基苯酚的高效节能、连续化清洁生产工艺研发》，横向委托，2004年11月，项目负责人
发明专利
中国授权发明专利60多项。
学术交流
1.浙江省科学技术奖三等奖，绿色化学技术及金属试剂在有机合成中的应用研究，2009年，排名第一
2.浙江省科学技术奖三等奖，《含氮杂环及β-羟基类化合物的绿色合成研究》2010年，排名第四
部分优秀硕士毕业生
(1) 04级硕士生 陈久喜（留校）：第二届温州市青年科技获得者（每两年入选10人），入选浙江省“新世纪151人才工程”和温州市“新世纪551人才工程”；
(2) 04级硕士生 陈锡安（留校）：入选温州市“新世纪551人才工程”，2011年考取湖南大学在职博士研究生；
(3) 05级硕士生 秦昌明：2011年考取Emory University博士研究生；
(4) 06级硕士生 朱东建：2011年考取中国科学院化学研究所博士研究生；
(5) 07级硕士生 程双华：2011年考取南京大学博士研究生；
(6) 07级硕士生 徐小玲（女）：2012年考取浙江大学博士研究生；
(7) 09级硕士生 康国伟：2013年考取Texas A&M University-Commerce博士研究生；
(8) 10级硕士生 刘洪鑫：2013年考取中国科学院成都生物研究所博士研究生；
(9) 10级硕士生：黄达云：2013年考取清华大学博士研究生。
(10) 10级硕士生：王兴永：2014年考取清华大学博士研究生。
(11) 11级硕士生：陈忠研：2014年考取南京大学博士研究生。
(12) 12级硕士生：杨渭光：2015年考取清华大学博士研究生。
(13) 13级硕士生：骆栋平：2016年考取清华大学博士研究生。
(14) 14级硕士生：闵琳：2017年考取清华大学博士研究生。
(15) 15级硕士生：单立东：2018年考取清华大学博士研究生。
(16) 15级硕士生：高超：2019年考取北京师范大学大学博士研究生。
(16) 16级硕士生：李鸿辰：2019年考取清华大学博士研究生。
(17) 16级硕士生：刘玮：2019年考取中山大学博士研究生。
常用链接
师资介绍 
化学系