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个人简介

高文霞，女，教授，毕业于合肥工业大学，主要从事生物医用材料研究。

主要研究及论文

1.  Xu  Long, Yang Yidi, Zhao Mingying, Zhang Hai, Li Sai, Wenxia Gao*, Bin He; Yuji Pu *. A reactive oxygen species–responsive prodrug micelle with efficient cellular uptake and excellent bioavailability, J. Mater. Chem. B, 2018, 6, 1076-1084.

2. Long Xu, Mingying Zhao, Yidi Yang, Yan Liang, Changzhen Sun, Wenxia Gao*, Sai Li, Bin He, Yuji Pu*. A reactive oxygen species (ROS)-responsive low molecular weight gel co-loaded with doxorubicin and Zn(II) phthalocyanine tetrasulfonic acid for combined chemo-photodynamic therapy, J. Mater. Chem. B, 2017, 5, 9157-9164.

3. Na Hao ; Changzhen Sun; Zhenfei Wu; Long Xu; ; Jun Cao; Wenxia Gao*, Li Li*; Bin He. Fabrication of Polymeric Micelles with Aggregation-Induced Emission and Forster Resonance Energy Transfer for Anticancer Drug Delivery, Bioconjugate Chemistry, 2017, 28, 1944-1954.

4. Taotao Xu ; Junhua Li; Jun Cao; Wenxia Gao*; Li Li* ; Bin He. The effect of α-cyclodextrin on poly(pseudo)rotaxane nanoparticles self-assembled by protoporphyrin modified poly(ethylene glycol) for anticancer drug delivery, Carbohydrate Polymers, 2017, 174, 789-797.

5. Ning Tao ; Guotao Li; Miaochang Liu; Wenxia Gao*; Huayue Wu* . Preparation of dual responsive low-molecular-weight hydrogel for long-lasting drug delivery, Tetrahedron, 2017, 73, 3173-3180.

6. Yan Liang, Wenxia Gao*, Xinyu Peng, Xin Deng, Changzhen Sun, Huayue Wu, Bin He*. Near infrared light responsive hybrid nanoparticles for synergistic therapy. Biomaterials, 2016, 100, 76-90.

7.  Wenxia Gao, Yan Liang*, Xinyu Peng, Yalong Hu, Longgui Zhang, Huayue Wu, Bin He*. In situ injection of phenylboronic acid based low molecular weight gels for efficient chemotherapy. Biomaterials, 2016, 105, 1-11.

8. Yalong Hu, Wenxia Gao*, Fang Wu, Huayue Wu, Bin He, Jing He*. Low molecular weight gels induced differentiations of mesenchymal stem cells. J. Mater. Chem. B, 2016, 4, 3504-3508.

9.  Long Xu, Yalong Hu, Miaochang Liu, Jiuxi Chen, Xiaobo Huang, Wenxia Gao*, Huayue Wu*. Gelation properties and glucose-sensitive behavior of phenylboronic acid based low-molecular-weight organogels. Tetrahedron, 2015, 71, 2079-2088.

10. Kaiwen Yang, Sicheng Wan, Binbin Chen, Wenxia Gao*, Jiuxi Chen, Miaochang Liu, Huayue Wu*. Dual pH and temperature responsive hydrogels based β-cyclodextrin derivatives for atorvastatin delivery. Carbohy. Polym., 2015, 136, 300-306.

11. Chaoyu Zhou, Wenxia Gao*, Kaiwen Yang, Long Xu, Jiuxi Chen, Miaochang Liu, Xiaobo Huang, Huayue Wu*. A novel glucose/pH responsive low-molecular-weight organogel of easy recycling. Langmuir, 2013, 29, 13568-13575.

12. Chaoyu Zhou, Wenxia Gao*, Guangming Lu, Xiuming Wu, Xiaobo Huang, Jiuxi Chen, Huayue Wu*. Preparation, characterization and in vitro release of microparticles based on dextran-rosuvastatin conjugate. Carbohy. Polym., 2013, 96, 156-162.

13. Xiepeng Lin, Wenxia Gao*, Chenen Li, Jiuxi Chen, Chen Yang, Huayue Wu*. Nano-sized flake carboxymethyl cassava starch as excipient for solid dispersions. Int. J. Pharmaceut., 2012, 423, 435-439.

14. Wenxia Gao,Xiaoqing Lin, Xiepeng Lin, Jinchang Ding, Xiaobo Huang, Huayue Wu*. Preparation of nano-sized flake carboxymethyl cassava starch under ultrasonic irradiation. Carbohy. Polym., 2011, 84, 1413-1418.

15. Xiepeng Lin, Wenxia Gao*, Xiaobo Huang, Panlong Zang, Jiuxi Chen, Huayue Wu*. Morphology-controlled hollow nanospheres of functionalized dextran by self-assembly in aqueous solution. Carbohy. Polym., 2010, 82, 460-465.

主要科研项目

1.国家自然科学基金面上项目，21672164，近红外光多点触发高灵敏刺激响应的功能分子设计、合成及载药系统研究，2017.01.01-2020.12.31，65万元，在研，主持

2.温州市科技局项目，Y20170162，高效抗非小细胞肺癌双硫仑-高分子胶束纳米药物研究，2017.07.01-2019.12.31，2万元，在研，主持

3.浙江省自然科学基金，LY15B020001，基于有机小分子凝胶非共价方式“门控”的智能介孔骨架型药物载体的构建及性能研究，2015.01.01-2017.12.31，8万元，已结题，主持

4.国家自然科学基金青年基金，21202122，葡萄糖快速响应型有机小分子凝胶的设计、合成及性能研究，2013.01.01-2015.12.31，25万元，已结题，主持

5.浙江省科技厅公益项目，2013C33188，有机硼酸小分子凝胶类胰岛素控释材料的设计合成与应用开发研究，2013.01.01-2014.12.31，10万元，已结题，主持

6.温州市科技局项目，G20090079，5-氨基-2-氯-N-(2,4-二甲苯基)-苯磺酰胺清洁生产工艺开发，2009-2011，10万元，已结题，主持

发明专利

1.高文霞, 吴华悦, 周超宇, 陈久喜, 刘妙昌, 黄小波, 蒋俊, 万思成。一种苯硼酸类有机凝胶化合物, ZL201210375089.0.

2.高文霞, 徐龙, 吴华悦, 陈久喜, 刘妙昌, 黄小波, 蒋俊。 一类苯硼酸类有机凝胶化合物, ZL201310361889.1.

3.高文霞, 吴华悦, 万思成, 陈久喜, 刘妙昌, 黄小波, 陈彬彬, 杨凯文。一种环境敏感型环糊精衍生物水凝胶的制备方法, ZL201410504485.8.

4.吴华悦; 高文霞; 刘妙昌; 陈久喜; 韩丹丹; 狄安利; 池艳艳; 金杰, 一种杀扑磷纳米乳剂及其制备方法, ZL201210376780.0

5.高文霞; 吴华悦; 陈久喜; 刘妙昌; 林勰鹏; 杨臣, 一种纳米级片状羧甲基淀粉钠在固体分散体中的应用, ZL 201110339510.8

6.高文霞; 吴华悦; 李晨恩; 刘妙昌; 陈久喜, 一种氯氰菊酯水乳剂及其制备方法, ZL 201110331083.9

7.吴华悦; 高文霞; 刘妙昌; 陈久喜; 周超宇; 卢广敏, 一种瑞舒伐他汀-右旋糖酐酯的制备方法, ZL 201110329343.9

8.高文霞; 吴华悦; 陈久喜; 刘妙昌; 林勰鹏, 一种纳米级片状羧甲基淀粉钠的制备方法, ZL 201110009231.5 

主要获奖情况

2015，浙江省151人才第三层次

2014，温州市551人才第二层次

2012，温州市551人才第三层次   

2012，第十四届温州市自然科学优秀论文奖

2010，浙江省第六届青年教师教学技能奖