题目: New Chemistry beyond Metathesis Catalyzed by Ruthenium Alkylidenes

报告人:Daesung Lee

报告地点:11B-204

报告时间:2016年7月11日上午10:00

个人简介:

Daesung Lee, Professor of Chemistry, University of Illinois at Chicago

(//www2.chem.uic.edu/leegroup/)

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Education

1988 BS, Chemistry, Seoul National University, Seoul, Korea

1990 MS, Chemistry, Seoul National University, Seoul, Korea

1998 PhD, Chemistry, Stanford University (Advisor: Prof. Paul A. Wender)

1998–2000 Postdoctoral Fellow, Harvard University (Advisor: Prof. Stuart L. Schreiber)

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Professional Experience

06/2000–05/2007 Assistant Professor of Chemistry, University of Wisconsin-Madison, WI

06/2007–07/2014 Associate Professor of Chemistry, University of Illinois at Chicago, IL

08/2014– Professor of Chemistry, University of Illinois at Chicago, IL

(1988年首尔国立大学本科、1998年斯坦福大学博士、2000年哈佛大学博士后、2014年芝加哥伊利诺伊大学教授，发表论文100余篇，其中JACS、Angew共30余篇)

报告摘要:

The main utility of Grubbs-type ruthenium alkylidenes involves metathesis chemistry. These rutheniumcomplexes, however, have proven their potential as a precatalyst for many non-metathetictransformations such as hydrogenation, dihydroxylation, and cyclopropanation. In light of expanding thescope of enyne metathesis, we streamlined enyne metathesis and metallotropic [1,3]-shift such thatvarious enyne-based functional groups could be constructed by the tandem catalysis of rutheniumalkylidenes. While exploring these tandem reactions of bis-1,3-diyne substrates, unprecedentedhydrovinylation reaction was discovered when ethylene was employed as an alkene counterpart. Moreinterestingly, these bis-1,3-diynes could undergo hexadehydro Diels-Alder reaction to form aryneintermediates, which were hydrohalogenated by ruthenium alkylidenes complexes in the presence ofhalohydrocarbons. In this presentation, the scope and utility of these powerful and noveltransformations will be discussed in the context of their discovery and application to natural productsynthesis.

Abstract-DLee.pdf
Brief CV-Daesung Lee.pdf