报告人：伊利诺伊大学芝加哥分校 Daesung Lee教授

邀请人：夏远志

报告题目：New Chemistry of Ruthenium Alkylidenes beyond Metathesis

报告时间：2018年5月10日（星期四）上午10:10-10:40

报告地点：化材楼11B204

Daesung Lee教授简介：

1988 BS, Chemistry, Seoul National University, Seoul, Korea

1990 MS, Chemistry, Seoul National University, Seoul, Korea

1998 PhD, Chemistry, Stanford University (Advisor: Prof. Paul A. Wender)

1998–2000 Postdoctoral Fellow, Harvard University (Advisor: Prof. Stuart L. Schreiber)

Professional Experience

06/2000–05/2007 Assistant Professor of Chemistry, University of Wisconsin-Madison, WI

06/2007–07/2014 Associate Professor of Chemistry, University of Illinois at Chicago, IL

08/2014– Professor of Chemistry, University of Illinois at Chicago, IL

报告摘要：

The main utility of Grubbs-type ruthenium alkylidenes deals with metathesis chemistry. These ruthenium complexes, however, have proven their potential as a precatalyst for many non-metathesis processes such as hydrogenation, dihydroxylation, cyclopropanation, and hydrovinylation, In light of expanding the scope of enyne metathesis, we streamlined enyne metathesis and metallotropic [1,3]-shift such that various enyne-based functional groups could be constructed by the tandem catalytic sequence of ruthenium alkylidenes. While exploring these tandem reactions of bis-1,3-diyne substrates, an unprecedented hydrovinylation reaction was discovered when ethylene was employed as an alkene counterpart. More interestingly, these bis-1,3-diynes can undergo hexadehydro Diels-Alder reaction to form aryne intermediates, which are hydrohalogenated by halohydrocarbons activated by ruthenium alkylidene complexes. In this presentation, the scope and utility of these novel transformations will be discussed in the context of their discovery and application to natural product synthesis.